[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers
Status:
Unknown status
Trial end date:
2019-06-30
Target enrollment:
Participant gender:
Summary
The main purpose of this study is to test the safety and tolerability of T-087. The study
will enroll 6 healthy volunteers (HVs) and 6-18 subjects with KOA. All eligible subjects will
receive an intravenous injection of the radioactive investigational product (ip) (T-087),
followed by SPECT/CT imaging of the knees and blood tests and clinical assessments for safety
monitoring. Healthy volunteers will also have their whole body imaged and have extra blood
drawn to determine where T-087 goes in the body. These additional procedures will be done on
the same day as the ip administration, and repeated the following day. All subjects will have
a final follow-up phone call within 2- 3 business days following the ip administration.